Effect of Etanercept on Atrial Natriuretic Peptide Induced Changes in Heart Rate and Biochemical Parameters

The atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, is a cardiovascular hormone which possesses well defined natriuretic, diuretic and vasodilating properties. Most of the biological effects of ANP are mediated through its guanylyl cyclase coupled receptor. ANP and its receptors have been shown to be expressed and differentially regulated in the immune system, and it has been suggested that ANP has an immuno-modulatory potency. A regulatory role for ANP has been suggested for the secretion of Tumor necrosis factoralpha (TNF-alpha) in whole blood. In this study, we investigated the effect of pre-treatment with etanercept on ANP induced changes in heart rate, serum uric acid and creatinine levels. Our study suggests that etanercept modulated the ANP induced change in heart rate and serum creatinine but did not significantly affect the serum uric acid levels.